Metabolism & epigenetics
نویسندگان
چکیده
Epigenetic regulation of gene activity is of immense importance in maintaining normal and dynamic transcription profiles of practically all cells in our body. In the meantime, cells metabolize nutrients to sustain through different tasks and challenges of life. Both metabolism and gene activity respond to changes in environment. By assessing the relative abundance of certain key compounds central to cellular energy flux, cells adjust transcription of selective genes by modulating epigenetic parameters including DNA and histone modifications. This commentary summarizes the epigenetic impacts of fluctuations of acetyl coenzyme A, S-adenosyl methionine, and nicotinamide adenine dinucleotide.
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